Introduction: Since the previous parameter and review paper publication on oral appliances (OAs) in 2006, the relevant scientific literature has grown considerably, particularly in relation to clinical outcomes. The purpose of this new guideline is to replace the previous and update recommendations for the use of OAs in the treatment of obstructive sleep apnea (OSA) and snoring. Methods: The American Academy of Sleep Medicine (AASM) and American Academy of Dental Sleep Medici

www.aadsm.org/oatguideline.aspx Kannan Ramar, MBBS, MD1; Leslie C. Dort, DDS2; Sheri G. Katz, DDS3; Christopher J. Lettieri, MD4; Christopher G. Harrod, MS5; Sherene M. Thomas, PhD5; Ronald D. Chervin, MD6 1Mayo Clinic, Rochester, MN; 2University of Calgary, Calgary, Alberta, Canada; 3Atlanta, GA; 4Walter Reed National Military Medical Center, Bethesda, MD; 5American Academy of Sleep Medicine, Darien, IL; 6University of Michigan, Ann Arbor, MI Introduction: Since the previous

www.nejm.org/doi/full/10.1056/NEJMoa1606599 This study ran 5 years, involved 89 clinical centres in 7 countries. The size of this study was huge, 2717 adults between the ages of of 45 and 75. All patients had a diagnosis of heart disease and moderate-to-severe Obstructive Sleep Apnea. Most patients (81%) were men. At the end of this study, a composite index was used as an end point measurement . (death from heart disease, heart attack, stroke, angina, snoring, quality of life

http://www.nejm.org/doi/full/10.1056/NEJMoa1606599#t=article BACKGROUND Obstructive sleep apnea is associated with an increased risk of cardiovascular events; whethertreatmentwithcontinuouspositiveairwaypressure(CPAP)preventsmajorcardio- vascular events is uncertain. METHODS After a 1-week run-in period during which the participants used sham CPAP, we ran- domly assigned 2717 eligible adults between 45 and 75 years of age who had moderate-to- severe obstructive sleep apnea an

Phillips CL, Grunstein RR, Darendeliler MA, Mihailidou AS, Srinivasan VK, Yee BJ, Marks GB, Cistulli PA. Am J Respir Crit Care Med. 2013 Apr 15;187(8):879-87. doi: 10.1164/rccm.201212-2223OC. PMID: 2341326 Rationale: Continuous positive airway pressure (CPAP) and mandibular advancement device (MAD) therapy are commonly used to treat obstructive sleep apnea (OSA). Differences in efficacy and compliance of these treatments are likely to influence improvements in health outcomes

This fascinating study that was done at three research facilities in Australia. CPAP (Continuous Positive Airway Pressure) and Mandibular Advancement Devices (MAD), or Oral Appliances are commonly used to treat Obstructive Sleep Apnea (OSA). 126 patients with moderate to severe OSA where treated with CPAP for one month and then where switched over to an Oral Appliance for one month and visa-versa. The treatment order was randomly assigned as to which patients started with CPA